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It literally takes every ounce of strength I have to make it through 8 hours at a desk cytotec medication Background In 1982, the National Surgical Adjuvant Breast and Bowel Project initiated a randomized, double blinded, placebo controlled trial B 14 to determine the effectiveness of adjuvant tamoxifen therapy in patients with primary operable breast cancer who had estrogen receptor positive tumors and no axillary lymph node involvement